MimeTech

Giuseppe Castronovo

Giuseppe Castronovo

Clinical Operations Director

Born in Agrigento, Italy, 1983.

  • MD in Medical Biotechnologies, University of Firenze;
  • PhD in Pharmacology, Toxicology and Innovative Treatments, University of Firenze;
  • 2nd Level Master in Pre-clinical and Clinical Drug Research and Development, University of Milano Bicocca.

Since 2010 he is a staff scientist at MimeTech, where he gained extensive knowledge of drug development, clinical trial design, and regulatory practices.

His activity is mainly focused on the pharmacological and toxicological evaluation of neurotrophin mimetic compounds.

Publications

  1. Zakrzewska K, Arvia R, Torcia MG, Clemente AM, Tanturli M, Castronovo G, Sighinolfi G, Giuggioli D, Ferri C. Effects of Parvovirus B19 In Vitro Infection on Monocytes from Patients with Systemic Sclerosis: Enhanced Inflammatory Pathways by Caspase-1 Activation and Cytokine Production. J Invest Dermatol. 2019 Oct;139(10):2125-2133.e1. doi: 10.1016/j.jid.2019.03.1144. Epub 2019 Apr 9. PubMed PMID: 30978354.
  2. Morelli A, Sarchielli E, Guarnieri G, Coppi E, Pantano D, Comeglio P, Nardiello P, Pugliese AM, Ballerini L, Matucci R, Ambrosini S, Castronovo G, Valente R, Mazzanti B, Bucciantini S, Maggi M, Casamenti F, Gallina P, Vannelli GB. Young Human Cholinergic Neurons Respond to Physiological Regulators and Improve Cognitive Symptoms in an Animal Model of Alzheimer’s Disease. Front Cell Neurosci. 2017 Oct 27;11:339. doi: 10.3389/fncel.2017.00339. eCollection 2017. PubMed PMID: 29163051; PubMed Central PMCID: PMC5666298.
  3. Di Paola M, Sani C, Clemente AM, Iossa A, Perissi E, Castronovo G, Tanturli M, Rivero D, Cozzolino F, Cavalieri D, Carozzi F, De Filippo C, Torcia MG. Characterization of cervico-vaginal microbiota in women developing persistent high-risk Human Papillomavirus infection. Sci Rep. 2017 Aug 31;7(1):10200. doi: 10.1038/s41598-017-09842-6. PubMed PMID: 28860468; PubMed Central PMCID: PMC5579045.
  4. Clemente AM, Castronovo G, Antonelli A, D’Andrea MM, Tanturli M, Perissi E, Paccosi S, Parenti A, Cozzolino F, Rossolini GM, Torcia MG. Differential Th17 response induced by the two clades of the pandemic ST258 Klebsiella pneumoniae clonal lineages producing KPC-type carbapenemase. PLoS One. 2017 Jun 6;12(6):e0178847. doi: 10.1371/journal.pone.0178847. eCollection 2017. PubMed PMID: 28586386; PubMed Central PMCID: PMC5460819.
  5. Castronovo G, Clemente AM, Antonelli A, D’Andrea MM, Tanturli M, Perissi E, Paccosi S, Parenti A, Cozzolino F, Rossolini GM, Torcia MG. Differences in Inflammatory Response Induced by Two Representatives of Clades of the Pandemic ST258 Klebsiella pneumoniae Clonal Lineage Producing KPC-Type Carbapenemases. PLoS One. 2017 Jan 12;12(1):e0170125. doi: 10.1371/journal.pone.0170125. eCollection 2017. PubMed PMID: 28081233; PubMed Central PMCID: PMC5231394.
  6. Clemente AM, Severini C, Castronovo G, Tanturli M, Perissi E, Cozzolino F, Torcia MG. Effects of soluble extracts from Leishmania infantum promastigotes, Toxoplasma gondii tachyzoites on TGF-β mediated pathways in activated CD4+ T lymphocytes. Microbes Infect. 2014 Sep;16(9):778-87. doi: 10.1016/j.micinf.2014.08.002. Epub 2014 Aug 12. PubMed PMID: 25130316.
  7. Clemente AM, Fadigati G, Caporale R, Marchese DG, Castronovo G, Sannella AR, Severini C, Verra F, Garaci E, Cozzolino F, Torcia MG. Modulation of the immune and inflammatory responses by Plasmodium falciparum schizont extracts: role of myeloid dendritic cells in effector and regulatory functions of CD4+ lymphocytes. Infect Immun. 2013 May;81(5):1842-51. doi: 10.1128/IAI.01226-12. Epub 2013 Mar 18. PubMed PMID: 23509139; PubMed Central PMCID: PMC3648022.