Sara Paccosi

Sara Paccosi

Born in Prato, Italy, 1980.

  • 2009 – MD in Biological Sciences, University of Firenze
  • 2012 – PhD in Pharmacology, Toxicology and Innovative Treatments, University of Firenze
  • 2017 – 1st Level Master in Biostatistics for Clinical Research and Scientific Reporting, University of Padova

Since 2019 she is a staff scientist at MimeTech.


  1. Sisti G, Paccosi S, Parenti A, Seravalli V, Di Tommaso M, Witkin SS. Insulin-like growth factor binding protein-1 predicts preterm premature rupture of membranes in twin pregnancies. Arch Gynecol Obstet. 2019 Sep;300(3):583-587. doi: 10.1007/s00404-019-05214-9. Epub 2019 Jun 14. PubMed PMID: 31201536.
  2. Sisti G, Di Tommaso M, Paccosi S, Parenti A, Seravalli V, Cuzzola R, Witkin SS. Unique Associations between Insulin-Like Growth Factor Binding Protein-1, Insulin-Like Growth Factor-1 and T Cell Immunoglobulin Mucin 3 in Successful Twin Pregnancies Conceived with Donor Oocytes. Medicina (Kaunas). 2019 May 16;55(5). pii: E144. doi: 10.3390/medicina55050144. PubMed PMID: 31100848; PubMed Central PMCID: PMC6572077.
  3. Paccosi S, Cresci B, Pala L, Rotella CM, Parenti A. Obesity Therapy: How and Why? Curr Med Chem. 2020;27(2):174-186. doi: 10.2174/0929867326666190124121725. PubMed PMID: 30678612.
  4. Sisti G, Di Tommaso M, Paccosi S, Parenti A, Di Rienzo G, Campana D, Witkin SS. Sex-specific influence of the vacuolar adenosine triphosphatase a2 isoform on outcome in twin pregnancies. Am J Reprod Immunol. 2019 Jan;81(1):e13071. doi: 10.1111/aji.13071. Epub 2018 Nov 26. PubMed PMID: 30418688.
  5. Paccosi S, Parenti A. Leukocyte-Independent Effects of CC-Chemokines on Vascular Remodeling. Curr Pharm Biotechnol. 2018;19(9):715-727. doi: 10.2174/1389201019666181017161447. Review. PubMed PMID: 30332947.
  6. Sisti G, Minis E, Di Tommaso M, Magro Malosso ER, Parenti A, Paccosi S, Pachon Romero MI, Witkin SS. T-cell immunoglobulin mucin-3 and galectin-9 levels in peripheral blood mononuclear cells predict fetal acidemia in twin pregnancies. J Matern Fetal Neonatal Med. 2018 Oct 29:1-5. doi: 10.1080/14767058.2018.1526919. [Epub ahead of print] PubMed PMID: 30231785.
  7. Fogli S, Montis C, Paccosi S, Silvano A, Michelucci E, Berti D, Bosi A, Parenti A, Romagnoli P. Inorganic nanoparticles as potential regulators of immune response in dendritic cells. Nanomedicine (Lond). 2017 Jul;12(14):1647-1660. doi: 10.2217/nnm-2017-0061. Epub 2017 Jun 21. PubMed PMID: 28635380.
  8. Clemente AM, Castronovo G, Antonelli A, D’Andrea MM, Tanturli M, Perissi E, Paccosi S, Parenti A, Cozzolino F, Rossolini GM, Torcia MG. Differential Th17 response induced by the two clades of the pandemic ST258 Klebsiella pneumoniae clonal lineages producing KPC-type carbapenemase. PLoS One. 2017 Jun 6;12(6):e0178847. doi: 10.1371/journal.pone.0178847. eCollection 2017. PubMed PMID: 28586386; PubMed Central PMCID: PMC5460819.
  9. Parenti A, Pala L, Paccosi S, Rotella CM. Potential Role for Dendritic Cells in Endothelial Dysfunction, Diabetes and Cardiovascular Disease. Curr Pharm Des. 2017;23(10):1435-1444. doi: 10.2174/1381612823666170124125826. Review. PubMed PMID: 28120714.
  10. Castronovo G, Clemente AM, Antonelli A, D’Andrea MM, Tanturli M, Perissi E, Paccosi S, Parenti A, Cozzolino F, Rossolini GM, Torcia MG. Differences in Inflammatory Response Induced by Two Representatives of Clades of the Pandemic ST258 Klebsiella pneumoniae Clonal Lineage Producing KPC-Type Carbapenemases. PLoS One. 2017 Jan 12;12(1):e0170125. doi: 10.1371/journal.pone.0170125. eCollection 2017. PubMed PMID: 28081233; PubMed Central PMCID: PMC5231394.
  11. Bigagli E, Cinci L, Paccosi S, Parenti A, D’Ambrosio M, Luceri C. Nutritionally relevant concentrations of resveratrol and hydroxytyrosol mitigate oxidative burst of human granulocytes and monocytes and the production of pro-inflammatory mediators in LPS-stimulated RAW 264.7 macrophages. Int Immunopharmacol. 2017 Feb;43:147-155. doi: 10.1016/j.intimp.2016.12.012. Epub 2016 Dec 18. PubMed PMID: 27998828.
  12. Parenti A, Indorato B, Paccosi S. Minocycline affects human neutrophil respiratory burst and transendothelial migration. Inflamm Res. 2017 Feb;66(2):107-109. doi: 10.1007/s00011-016-0999-x. Epub 2016 Oct 18. PubMed PMID: 27757474.
  13. Paccosi S, Giachi M, Di Gennaro P, Guglielmotti A, Parenti A. The chemokine (C-C motif) ligand protein synthesis inhibitor bindarit prevents cytoskeletal rearrangement and contraction of human mesangial cells. Cytokine. 2016 Sep;85:92-100. doi: 10.1016/j.cyto.2016.06.012. Epub 2016 Jun 13. PubMed PMID: 27309675.
  14. Caiazzo E, Maione F, Morello S, Lapucci A, Paccosi S, Steckel B, Lavecchia A, Parenti A, Iuvone T, Schrader J, Ialenti A, Cicala C. Adenosine signalling mediates the anti-inflammatory effects of the COX-2 inhibitor nimesulide. Biochem Pharmacol. 2016 Jul 15;112:72-81. doi: 10.1016/j.bcp.2016.05.006. Epub 2016 May 14. PubMed PMID: 27188793.
  15. Cinci L, Luceri C, Bigagli E, Carboni I, Paccosi S, Parenti A, Guasti D, Coronnello M. Development and characterization of an in vitro model of colorectal adenocarcinoma with MDR phenotype. Cancer Med. 2016 Jun;5(6):1279-91. doi: 10.1002/cam4.694. Epub 2016 Mar 25. PubMed PMID: 27016279; PubMed Central PMCID: PMC4924386.
  16. Parenti A, Paccosi S, Cairo F, Defraia E. Treatment of Periodontitis for the Prevention of Endothelial Dysfunction: A Narrative Review. Curr Vasc Pharmacol. 2015;13(6):749-58. Review. PubMed PMID: 26282351.
  17. Musilli C, Paccosi S, Graziani G, Caporale R, Gelli AM, Parenti A. Endothelial Soluble Factors Mediate Differentiation of Circulating Endothelial Precursors. J Cardiovasc Pharmacol. 2015 Aug;66(2):223-7. doi: 10.1097/FJC.0000000000000263. PubMed PMID: 25874854.
  18. Paccosi S, Musilli C, Caporale R, Gelli AM, Guasti D, Clemente AM, Torcia MG, Filippelli A, Romagnoli P, Parenti A. Stimulatory interactions between human coronary smooth muscle cells and dendritic cells. PLoS One. 2014 Jun 16;9(6):e99652. doi: 10.1371/journal.pone.0099652. eCollection 2014. PubMed PMID: 24932497; PubMed Central PMCID: PMC4059651.
  19. Paccosi S, Musilli C, Mangano G, Guglielmotti A, Parenti A. The monocyte chemotactic protein synthesis inhibitor bindarit prevents mesangial cell proliferation and extracellular matrix remodeling. Pharmacol Res. 2012 Dec;66(6):526-35. doi: 10.1016/j.phrs.2012.09.006. Epub 2012 Sep 14. PubMed PMID: 22982961.
  20. Musilli C, Karam JP, Paccosi S, Muscari C, Mugelli A, Montero-Menei CN, Parenti A. Pharmacologically active microcarriers for endothelial progenitor cell support and survival. Eur J Pharm Biopharm. 2012 Aug;81(3):609-16. doi: 10.1016/j.ejpb.2012.04.014. Epub 2012 Apr 26. PubMed PMID: 22561954.
  21. Musilli C, Paccosi S, Pala L, Gerlini G, Ledda F, Mugelli A, Rotella CM, Parenti A. Characterization of circulating and monocyte-derived dendritic cells in obese and diabetic patients. Mol Immunol. 2011 Oct;49(1-2):234-8. doi: 10.1016/j.molimm.2011.08.019. Epub 2011 Sep 21. PubMed PMID: 21940050.